8. Ge Y, Chen L, Liu S, Zhao J, Zhang H, Chen P*. “Enzyme-mediated intercellular proximity labeling for detecting cell-cell interactions”,J. Am. Chem. Soc. (2019), 141, 1833-37.

7. Zhao J, Liu Y, Lin F, Wang W, Yang S, Ge Y, Chen P*. “Bioorthogonal Engineering of Bacterial Effectors for Spatial–Temporal Modulation of Cell Signaling”, ACS Cent. Sci. (2019), 5, 145-53.

6. He D, Zhang M, Liu S, Xie X, Chen P*. “Protease-mediated protein quality control for bacterial acid resistance”, Cell Chem. Biol. (2019), 26,144-50.

5. Yao Q, Lin F, Fan X, Wang Y, Liu Y, Liu Z, Jiang X, Chen P*Gao Y*. “Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems”, Nat. Commun. (2018), 9, 5032.

4. Hao Z, Zhu R, Chen P*. “Genetically encoded fluorescent sensors for measuring transition and heavy metals in biological systems”, Curr. Opin. Chem. Biol. (2018), 43, 87-96.

3. Ngai WSC, Chen P*. “Optimizing orthogonality”, Nat Chem. (2018), 10, 802-3.

2. Liu L, Liu Y, Zhang G, Ge Y, Fan X, Lin F, Wang J, Zheng H, Xie X, Zeng X, Chen P*. “Genetically encoded chemical decaging in living bacteria”, Biochemistry. (2018),57, 446-50.

1. Zheng H, Lin S, Chen P*. “Genetic code expansion in enteric bacterial pathogens”, Methods Mol Biol. (2018), 1728, 113-26.


8. R. Zhu, Y. Song, H. Liu, Y. Yang, S. Wang, C. Yi, Chen P*. “Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation”,Proc. Natl. Acad. Sci. (2017), 114, 13661-6.

7. He D, Xie X, Yan F, Zhang H, Su H, Ge Y, Song H, Chen P*. “Quantitative and Comparative Profiling of Protease Substrates through a Genetically Encoded Multifunctional Photocrosslinker”,Angew. Chem. Int. Ed. DOI: 10.1002/anie.201708151

6. Yang Y, Song H, He D, Zhang S, Dai S, Xie X, Lin S, Hao Z, Zheng H, Chen P*. “Genetically encoded releasable photo-cross-linking strategies for studying protein–protein interactions in living cells”,Nat. Protoc. (2017), 12, 2147–2168

5. Zheng S, Fan X, Wang J, Zhao J, Chen P*. “Dissection of Kinase Isoforms through Orthogonal and Chemical Inducible Signaling Cascades”,ChemBioChem (2017), 18, 1-7

4. Zhang S, He D, Lin Z, Yang Y, Song H, Chen P*. “Conditional Chaperone–Client Interactions Revealed by Genetically Encoded Photo-cross-linkers”,Acc. Chem. Res. (2017), 50, 1184–1192

3. Xie X, Li X, Qin F, Lin J, Zhang G, Zhao J, Bao X, Zhu R, Song H, Li X, Chen P*. “Genetically Encoded Photoaffinity Histone Marks”,J. Am. Chem. Soc. (2017), 139, 6522–6525

2. Zhu R, Hao Z, Lou H, Song Y, Zhao J, Chen Y, Zhu J, Chen P*. “Structural characterization of the DNA-binding mechanism underlying the copper(II)-sensing MarR transcriptional regulator”, J. Biol. Inorg. Chem.(2017), 22,685–693

1. Lin Z, Xie X,Chen P*. “Kicking down the ladder: adding cleavable features to genetically encoded photocrosslinkers”,Sci. China Chem. (2017), 60, 167–169


10. Wang J, Zheng S, Liu Y, Zhang Z, Lin Z, Li J, Zhang G, Wang X, Li J and Chen P*. “Palladium-triggered chemical rescue of intracellular proteins via genetically encoded allene-caged tyrosine”, J. Am. Chem. Soc. (2016), 138, 15118−15121

9. Fan X, Ge Y, Lin F, Yang Y, Zhang G, Ngai WSC, Lin Z, Zheng S, Wang J, Zhao J, Li J and Chen P*. “Optimized Tetrazine Derivatives for Rapid Bioorthogonal Decaging in Living Cells”, Angew. Chem. Int. Ed. (2016), 55, 14046-50.

8. Yang Y, Song H and Chen P*. “Genetically encoded photocrosslinkers for identifying and mapping protein-protein interactions in living cells”, IUBMB life (2016), 68, 879-86.

7. Zhang S, He D, Yang Y, Lin S, Zhang M, Dai S and Chen P*. “Comparative proteomics reveal distinct chaperone-client interactions in supporting bacterial acid resistance” ,Proc. Natl. Acad. Sci. (2016), 113, 10872-7.

6. Chen L, Cohen J, Song X, Zhao A, Ye Z, Feulner C, Doonan P, Somers W, Lin L* and Chen P*. “Improved variants of SrtA for site-specific conjugation on antibodies and proteins with high efficiency”. Sci. Rep. (2016), 6, 31899.

5. Ge Y, Fan X, and Chen P*. “A genetically encoded multifunctional unnatural amino acid for versatile protein manipulations in living cells”, Chem. Sci. (2016),7, 7055-60.

4. Yang Y, Song H, He D, Zhang S, Dai S, Lin S, Meng R, Wang C* and Chen P*. “Genetically encoded protein photocrosslinker with a transferable mass spectrometry-identifiable label”, Nat. Commun. (2016), 7, 12299.

3. Zhang G, Li J, Xie R, Fan X, Liu Y, Zheng S, Ge Y and Chen P*. “Bioorthogonal chemical activation of kinases in living systems”, ACS Cent. Sci. (2016), 2, 325-31.
[This work has been highlighted by Chem. & Eng. News, 2016, 94(19), 5]

2. Li J and Chen P*. “Development and application of bond cleavage reactions in bioorthogonal chemistry”, Nat. Chem. Biol. (2016), 12, 129-37.

1. Yang M*, Yang Y, Chen P*.“Transition-metal-catalyzed bioorthogonal cycloaddition reactions”, Top. Curr. Chem.(2016), 374, 27-55.


7. Song Y, Zhu R, Chen P*. “Physiological distribution and regulation of heme”, Sci. Sinica Chim. (2015), 45, 1194-205.

6. Lin R, Elf S, Shan C, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen P, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S*, Fan J*, Chen J*. “6-Phosphogluconate Dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling”, Nat. Cell. Biol. (2015), 17, 1484-96.

5. Hackenberger CPR* and Chen P*. “Editorial overview: Synthetic biomolecules: Synthetic protein modifications - a giant leap towards understanding and generating biological functions” ,Curr. Opin. Chem. Biol. (2015), 28, VII-IX.

4. Yang M and Chen P*. “Progress in the bioorthogonal labeling reactions” ,ACTA CHIMICA SINICA (2015), 73, 783-92.

3. Song Y, Yang M, Wegner SV, Zhao J, Zhu R, Wu Y, He C* and Chen P*. “A genetically encoded FRET sensor for intracellular heme”. ACS Chem. Biol. (2015), 10, 1610-5.

2. Wang J, Cheng B, Li J, Zhang Z, Hong W, Chen X* and Chen P*. “Chemically remodeling of cell-surface sialic acids by using the palladium-triggered bioorthogonal elimination reactions”, Angew. Chem. Int. Ed. (2015), 54, 5364-8.

1. Zhang G, Zheng S, and Chen P*. “Illuminating biological processes through site-specific protein labeling”, Chem. Soc. Rev. (2015), 44, 3405-17.


12. Li J, Jia S, Chen P* "Diels-Alder reaction-triggered bioorthogonal protein activation in living cells", Nat. Chem. Biol. (2014), 10, 1003-5. [This work has been highlighted by Nature Methods 2015, 12, 16 ]

11. Yang M, Jalloh A, Wei W, Zhao J*, Wu P*, Chen P*, “Biocompatible click chemistry enabled compartment-specific pH measurement inside E. coli”, Nat. Commun. (2014), 5, 4981. [This work has been highlighted by Chem. & Eng. News. 2014, 92(39), 30]

10. Lin S, He D, Long T, Zhang S, Meng R, Chen P*, "Genetically Encoded Cleavable Protein Photocrosslinker", J. Am. Chem. Soc. (2014), 136, 11860-3. [This work has been highlighted by Chem. & Eng. News. 2014, 92(34), 4]

9. Lin S, Chen P*. “Virus engineering: Fighting HIV at its own game.” Nat. Chem. (2014), 6. 566-8.

8. Zheng S, Zhang G, Li J, Chen P*. “Monitoring Endocytic Trafficking of Anthrax Lethal Factor by Precise and Quantitative Protein Labeling”. Angew. Chem. Int. Ed. (2014), 53, 6449-53.

7. Yang Y, Lin S, Lin W, Chen P*. “Ligand-Assisted Dual-Site Click Labeling of EGFR on Living Cells”. ChemBioChem. (2014), 15, 1738-43.

6. Li J, Yu J, Zhao J , Wang J, Zheng S, Lin S, Chen L, Yang M, Jia S, Zhang X and Chen P*. “Palladium-triggered Deprotection Chemistry for Protein Activation in Living Cells”, Nat. Chem. (2014), 6, 352-61. [This work has been highlighted by Nature Methods 2014, 11, 472 and Nature Chemical Biology 2014, 10, 328]

5. Hao Z, Lou H, Zhu R, Zhu J, Zhang D, Zhao B, Zeng S, Chen X, Chan J, He C* and Chen P*. “The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli”, Nat. Chem. Biol. (2014), 10, 21-8. [This work has been highlighted by (RSC) Chemistry World]

4. Yang M, Li J, Chen P*.“Transition Metal Mediated Biocompatible Protein Chemistry in Living Cells”. Chem. Soc. Rev. (2014), 43, 6511-26. Emerging Investigators Special Issue.

3. Cheng M, Zhang W, Yuan J, Luo W, Li N, Lin S, Yang Y, Fang X* and Chen P*.“Single-molecule dynamics of site-specific labeled transforming growth factor type II receptors on living cells”, Chem. Comm. (2014) ,50, 14724-7

2. Shan C, Elf S, Ji Q, Kang HB, Zhou L, Hitosugi T, Jin L, Lin R, Zhang L, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen P, Wang D, Chen GZ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J*, Chen J*. “Lysine Acetylation Activates 6-Phosphogluconate Dehydrogenase to Promote Tumor Growth.”, Mol. Cell (2014), 55, 552-65.

1. Fan Y, Zhao J, Yan Q, Chen P* and Zhao D*. “A Water-soluble Triscyclometalated Organoiridium Complex: Phosphorescent Nanoparticle Formation, Nonlinear Optics, and Application for Cell Imaging”,ACS Appl Mat. Inter. (2014), 6, 3122–31.


7. Lin S, Yan H, Li L, Yang M, Peng B, Chen S, Li W* and Chen P*, “Site-specific Engineering of Chemical Functionalities on the Surface of Live Hepatitis D Virus”, Angew. Chem. Int. Ed. (2013), 52, 13970-4.

6. Li J, Lin S, Wang J, Jia S, Yang M, Zhang X, Hao Z and Chen P* “Ligand-free Palladium-mediated Site-specific Protein Labeling inside Gram-negative Bacterial Pathogens”,J. Am. Chem. Soc. (2013), 135, 7330-8.

5. Zhao J, Lin S, Huang Y, Zhao J*, Chen P*. Mechanism-Based Design of a Photoactivatable Firefly Luciferase”, J. Am. Chem. Soc. (2013), 135, 7410-3

4. Ge X, Wang R, Ma J, Liu Y, Ezemaduka AN, Chen P, Fu X*, and Chang Z*. “DegP primarily functions as a protease for the biogenesis of β-barrel outer membrane proteins in the Gram-negative bacterium Escherichia coli”, FEBS J. (2013), 281, 1226–40.

3. Chang H, Han M, Huang W, Wei G, Chen J, Chen P, Chen R, Zhang J, Xu T* and Xu P*. “Light-induced protein translocation by genetically encoded unnatural amino acid in Caenorhabditis elegans”, Protein Cell. (2013), 4, 883-6

2. Zhao B, Zhang G, Zeng S, He C, and Chen P*. “Probing subcellular organic hydroperoxide formation via a genetically encoded ratiometric and reversible fluorescent indicator.”, Integr. Biol (2013), 5, 1485-9.

1. Liu J, Karpus J, Wegner S, Chen P* and He C*. “Genetically Encoded Copper(I) Reporters with Improved Responses for Use in Imaging”, J. Am. Chem. Soc. (2013), 135, 3144-9.


9. Yang M, Song Y, Zhang M, Lin S, Hao Z, Liang Y, Zhang D and Chen P*.“Converting a solvatochromic fluorophore into a protein-based pH indicator for extreme acidity”, Angew. Chem. Int. Ed. (2012) 51, 7674-9.

8. Li Y, Yang M, Huang Y, Song X, Liu L* and Chen P*. “Genetically encoded alkenyl-pyrrolysine analogues for thiol-ene reaction mediated site-specific protein labeling”, Chem. Sci. (2012), 3, 2766-70.

7. Li J and Chen P*. "Moving Pd-mediated Protein Cross-coupling to Living Systems", ChemBioChem. (2012), 13, 1728-31.

6. Wang J, Karpus J, Zhao B, Luo Z, Chen P and He C*. “A selective fluorescent probe for carbon monoxide imaging in living cells.” Angew. Chem. Int. Ed. (2012), 51, 9652-6.

5. Li Y, Yang M, Huang Y, Li, Y, Chen P*. and Liu, L*. “Ligation of Expressed Protein α-Hydrazides via Genetic Incorporation of an α-Hydroxy Acid.” ,ACS Chem. Biol. (2012), 7, 1015-22.

4. Wei W, Zhu T, Wang Y, Yang H, Hao Z, Chen P*. and Zhao, J*. “Engineering a gold-specific regulon for cell-basedvisual detection and recovery of gold”, Chem. Sci. (2012), 3, 1780-4.

3. Liu J, Zhang M and Chen P*. “Probing pH Mediated protein-protein interactions via photocrosslinking”, SCIENTIA SINICA Chimica. (2012), 42, 1694-9.

2. Li J, Wang J and Chen P*. “Unnatural amino acid mediated Protein Bioorthogonal Labeling” ,ACTA CHIMICA SINICA (2012), 70, 1439-45.

1. Chen X, Hao Z and Chen P*. “Protein photocrosslinking reveals dimer of dimers formation on MarR protein in Escherichia coli”, SCIENCE CHINA Chemistry (2012), 42, 223-5.


5. Lin S, Zhang Z, Xu H, Li L, Chen S, Li J, Hao Z and Chen P*. “Site-specific incorporation of photocrosslinker and bioorthogonal amino acids into enteric bacterial pathogens”, J. Am. Chem. Soc. (2011), 133, 20581-7.

4. Zhang M, Lin S, Song X, Liu J, Fu Y, Fu X, Chang Z*, and Chen P*. “A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance”, Nat. Chem. Biol. (2011), 7, 671-7. [This work is a “News Coverage” on Chem. & Eng. News. Sep 7, 2011,and has been highlighted by Nature Asia-Pacific on Sep 5, 2011]

3. Hao Z, Hong S, Chen X* and Chen P*. “Introducing Bioorthogonal Functionalities into Proteins in Living Cells”, Acc. Chem. Res. (2011), 44, 742-51.

2. Hao Z, Song Y, Lin S, Yang M, Liang Y, Wang J and Chen P*. “A readily synthesized cyclic pyrrolysine analogue for site-specific protein ‘click’ labeling”.Chem Commun (Camb) (2011), 47, 4502-4.

1. Chen P*, Brugarolas P and He C*. “Redox Signaling in Human Pathogens”,Antioxid Redox. Signal. (2011), 14, 1107-18.


1. Zhao B, Liang Y, Song Y, Zheng C, Hao Z and Chen P*. “A Highly Selective Fluorescent Probe for Visualization of Organic Hydroperoxides in Living Cells”, J. Am. Chem. Soc. (2010), 132, 17065-7.